Francesco Bottaccioli a, Anna Giulia Bottaccioli b

a Società Italiana di Psiconeuroendocrinoimmunologia, University of Turin

b Universities of Turin

Abstract

According to Kelley et al. (2023), BBI Integrative ‘recognises the historical importance of Eastern health practices in the entire field of PNI’ (psychoneuroimmunology). We applaud this editorial innovation and believe that it is an important step in advancing the ability to provide healing to human beings.

This article aims to illustrate suggestions for scientific research and integrative care derived from studying the ancient Chinese medicine and philosophy using pathophysiological and clinical examples. It shows how some fundamental categories of ancient Chinese philosophies, such as the yin–yang theory, and healing models, such as yang sheng (nurturing life), can help us understand how the immune system works and where the foundations of health are rooted. It also examines some examples of the yin–yang dialectic in immunology, such as T helper 1 (Th1) circuit control by the same cells that initially produce cytokines (IL-12 and IFN-γ) to activate this circuit and then produce Th2 circuit cytokines (IL-4) to moderate it. In addition, the transformation of regulatory T-cells into inflammatory T-cells (Th17) and the IL-6 dual pro- or anti-inflammatory face, depends on the context. In the first example, yin is present in yang. In the second, the yang is in the yin. Finally, we present an example of the cytokine yin–yang.

This article also shows the surprising concordances of ancient Chinese chronobiology with the modern science of circadian rhythms and the unknown connections between organs, such as between the lungs and gut, which has drawn the attention of modern scientific research only recently.

Finally, this article highlights the peculiar approach of ancient Chinese medicine to prevention and treatment, called yang sheng, which shows strong concordance with the model proposed by Psychoneuroendocrineimmunology.

Keywords

Yin–yang

Wu Xing

Yang sheng

Th and cytokine balance

Circadian Rhythms

Internal physiopathological connections

Integrated care

Philosophy and Medicine

Psychoneuroendocrineimmunology