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Chinese herbal medicine trial offers new hope in memory loss treatment
source:South China Morning Post 2023-10-13 [Health]
A phase 2 clinical trial in Australia has found that a Chinese herbal medicine compound significantly improved memory and executive functions in people with mild cognitive impairment (MCI).
  • .Australian phase 2 clinical trial of Sailuotong shows memory and executive function improvements in people with mild cognitive impairment (MCI)
  • .Patients with MCI have increased risk of dementia caused by Alzheimer’s disease or other brain disorders


Capsules containing a blend of Ginkgo biloba, ginseng and saffron extracts - called Sailuotong - have shown promise in improving memory and other functions in people diagnosed with mild cognitive impairment. Photo: Bloomberg


People diagnosed with MCI can experience early stage memory loss or declines in other cognitive abilities such as language, according to the Chicago-based Alzheimer’s Association.

Patients with MCI have an increased risk of dementia – more than fivefold in some cases – which can be a precursor to dementia and Alzheimer’s disease in particular.

Currently, there are no approved medications for MCI. Existing treatments for Alzheimer’s disease are not considered safe or effective.

“We know that it is a critical window of opportunity for early intervention to potentially delay or prevent dementia,” said cognitive neuroscientist Genevieve Steiner-Lim, an associate professor at Western Sydney University, who led the trial of the compound named Sailuotong (SLT).

“Our findings are very promising as they show that even after a relatively short period of just 12 weeks, SLT can support memory and thinking in people with MCI,” said Steiner-Lim, who is also a fellow at the university’s NICM Health Research Institute.

SLT is a modern Chinese herbal medicine taken in capsule form that contains extracts of ginseng, Ginkgo biloba and crocus sativus L, commonly known as saffron.

Previous studies have shown that SLT is safe and can improve cognitive functions and quality of life in those with vascular dementia, as well as modulate cognitive functions in healthy young adults, according to the scientists.

SLT has been co-developed and tested over the past 15 years by researchers at Western Sydney University’s NICM Health Research Institute and Xiyuan Hospital at the China Academy of Chinese Medical Sciences in Beijing.

“The expertise from both Australia and China has helped develop this potential new treatment based on the principles of Chinese medicine and conventional pharmaceutical technology,” Steiner-Lim said.

The scientists, along with peers from Nanyang Technological University in Singapore, as well as Macquarie University and Royal North Shore Hospital in Australia, published their trial results on Wednesday in the peer-reviewed journal Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring.

The 12-week trial involved 78 people aged 60 years or older who had been diagnosed with MCI.

The group that received SLT “improved the retrieval of verbal information from memory and aspects of executive function including switching between cognitive concepts, higher-level divided attention and multitasking” compared with the placebo group, according to Steiner-Lim. The herbal extract was also safe and well tolerated.

“The next step is to conduct another clinical trial with a larger sample size and longer treatment period and different doses to test whether SLT has the same positive effects on memory and thinking in people with MCI, or whether it could potentially delay a diagnosis of dementia,” she said, adding that more investment in this research was needed.